简介：Inthepresentstudy,weaimedtodeterminethequalityofdifferentbrands(Test1–Test6)ofmefenamicacid,whicharecommerciallyavailableinlocalmarketofKarachi,Pakistan.Variousqualityevaluationtests,includingweightvariation,hardness,thickness,friability,disintegration,assayanddrugrelease,werecarriedout.Resultswerefoundtobeinacceptablelimits.Moreover,releaseprofileswerecomparedusingdifferentdissolutionmedia,suchasphosphatebufferpH6.8,7.4andbiorelevantmedia(FaSSGF,FaSSIF,FeSSIFandSCoF).ReleaseprofilesatpH6.8and7.4wereevaluatedbyone--wayANOVA,model-independentandmodel--dependentmethods.ResultsofANOVAshowedthatnosignificantdifferencewasfoundamongtesterandreferencebrands(Test1–Test6).Similarly,allthebrandswerefoundtobebestfittedwithWeibullmodel.