简介：Wepresentherethedevelopmentofcholesterol(Chol)-modifieddendrimersystemfortargetedchemotherapyoffolate(FA)receptor-expressingcancercells.Inourstudy,poly(amidoamine)(PAMAM)dendrimersofgeneration5(G5)werefunctionalizedstepby-stepwithChol,fluoresceinisothiocyanate(FI),andFAviaapoly(ethyleneglycol)(PEG)spacer(PEG-FA),andthenacetamidetoshieldtheirremainingsurfaceamines.ThesynthesizedG5.NHAc-Chol-FI-PEG-FA(forshort,G5-CFPF)dendrimerswereutilizedtoencapsulate10-hydroxycamptothecin(HCP),ahydrophobicanticancerdrug.WefindthateachG5-CFPFdendrimercanencapsulate13.8HCPmolecules.ThecomplexesshowaslowerreleaseprofilesofHCPinapH-dependentmannerthanthecontrolcomplexesformedusingthesamedendrimerswithoutCholunderthesameconditions.ThankstothetargetingroleplayedbyFA,thecomplexesdisplayaspecificinhibitionefficacytoFAreceptor-expressingcervicalcancercells.ThedesignedChol-modifieddendrimersmaybeadoptedasapromisingcarrierforapplicationintargetedcancertherapy.

简介：变形癌症房间的俘获和察觉为恶意的瘤的诊断和治疗是关键的。这里，我们报导folic酸(FA)的使用poly修改了electrospun(乙烯基白酒)(PVA)为癌症房间俘获应用的/polyethyleneimine(PEI)nanofibers。由glutaraldehyde蒸汽的ElectrospunPVA/PEInanofiberscrosslinked与FA被修改经由一poly(乙烯乙二醇)(木钉)分隔符，由纤维表面PEI胺的acetylation列在后面。形成的修改FA的nanofibers很好被描绘。electrospunPVA/PEInanofibers的形态学尽管有表面修正光滑、一致。另外，修改FA的nanofibers显示由溶血证实了的好hemocompatibility试金。重要地，发达修改FA的nanofibers能明确地捕获癌症房间overexpressingFA受体，它被数试金和质的共焦的显微镜学分析的量的房间验证。发达修改FA的PVA/PEInanofibers可以被用于为癌症诊断应用程序捕获传播肿瘤房间。

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