简介:摘要目的观察原发性骨髓增生异常综合征(myelodysplasticsyndrome,MDS)合并自身免疫异常患者的临床特征,探讨合并自身免疫异常对MDS患者转归及生存期的影响。方法分析2017年1月~2019年4月在我院进行治疗的146例MDS患者的临床资料,根据是否合并自身免疫异常将其分为合并自身免疫异常组(n=31)和免疫学检查正常组(n=115),比较其一般情况、合并自身免疫性疾病情况、血常规指标、染色体核型分布以及转白率、中位生存时间等指标。结果146例MDS患者中,15例(10.27%)合并自身免疫性疾病,另有16例(10.96%)患者出现免疫学检查异常而无临床症状,二者合计31例,占比(21.23%)。合并自身免疫异常组患者<60岁者比例、女性比例明显高于免疫学检查正常组,差异具有统计学意义(P<0.05)。两组患者外周血血常规检查指标、染色体核型分布、转白率等指标无差异(P>0.05)。合并自身免疫异常组患者中位生存期明显短于免疫学检查正常组,差异具有统计学意义(P<0.05)。结论MDS患者合并自身免疫异常多见于年龄<60岁的女性,且合并自身免疫异常的MDS患者中位生存期缩短,提示自身免疫异常对MDS的预后可能存在不良影响。
简介:[摘要 ] 目的 观察原发性骨髓增生异常综合征( myelodysplastic syndrome, MDS)合并自身免疫异常患者的临床特征,探讨合并自身免疫异常对 MDS患者转归及生存期的影响。 方法 分析 2017年 1月~ 2019年 4月在我院进行治疗的 146例 MDS患者的临床资料,根据是否合并自身免疫异常将其分为合并自身免疫异常组( n = 31)和免疫学检查正常组( n = 115),比较其一般情况、合并自身免疫性疾病情况、血常规指标、染色体核型分布以及转白率、中位生存时间等指标。 结果 146例 MDS患者中, 15例( 10.27%)合并自身免疫性疾病,另有 16例( 10.96%)患者出现免疫学检查异常而无临床症状,二者合计 31例,占比( 21.23%)。合并自身免疫异常组患者 <60岁者比例、女性比例明显高于免疫学检查正常组,差异具有统计学意义( P < 0.05)。两组患者外周血血常规检查指标、染色体核型分布、转白率等指标无差异( P > 0.05)。合并自身免疫异常组患者中位生存期明显短于免疫学检查正常组,差异具有统计学意义( P < 0.05)。 结论 MDS患者合并自身免疫异常多见于年龄 <60岁的女性,且合并自身免疫异常的 MDS患者中位生存期缩短,提示自身免疫异常对 MDS的预后可能存在不良影响。 [关键词 ] 原发性骨髓增生异常综合征;自身免疫异常;临床特征;生存研究 [Abstract] Objective To observe the clinical characteristics of primary myelodysplastic syndrome (MDS) patients with autoimmune abnormalities, and to explore the effect of autoimmune abnormalities on the prognosis and survival of MDS patients. Methods The clinical data of 146 patients with MDS treated in our hospital from January 2017 to April 2019 were analyzed. They were divided into combined autoimmune abnormality group (n = 31) and normal immunological examination group (n = 115). The general situation, combined autoimmune diseases, blood routine indexes, chromosome karyotype distribution, whitening rate and median were compared. Survival time and other indicators. Results Among the 146 patients with MDS, 15 (10.27%) had autoimmune diseases, and 16 (10.96%) had abnormal immunological examinations without clinical symptoms, accounting for 31 (21.23%). The proportion of patients < 60 years old and women in the group with autoimmune abnormality was significantly higher than that in the group with normal immunological examination (P < 0.05). There were no differences in routine blood test, chromosome karyotype distribution and white rate between the two groups (P > 0.05). The median survival time of patients with autoimmune abnormality was significantly shorter than that of patients with normal immunological examination (P < 0.05). Conclusion Autoimmune abnormalities in MDS patients are more common in women aged less than 60 years, and the median survival time of MDS patients with autoimmune abnormalities is shortened, suggesting that autoimmune abnormalities may have adverse effects on the prognosis of MDS.