简介:目的探讨特勤人员S_ⅠS_ⅡS_Ⅲ综合征特点。方法选取Ⅰ、Ⅱ、Ⅲ标准导联同时存在S波的患者心电图,分析Ⅰ、Ⅱ、Ⅲ、aVR、V1、V5导联R波与S波比值、心电轴及年龄、体型以及病史等相关参数。结果(1)S_ⅠS_ⅡS_Ⅲ综合征发生率低,仅0.9%(51/5639人);(2)51例S_ⅠS_ⅡS_Ⅲ综合征患者心电轴偏移范围宽,在-110°~+178°,平均(27.49±79.74)°,其中心电轴正常19例(37.3%)、右偏15例(29.4%)、左偏13例(25.5%)、心电轴不确定4例(7.8%);(3)S_ⅠS_ⅡS_Ⅲ综合征多见于体质量指数偏低即呈瘦长体型年轻人,体质量指数〈24.0者占58.8%(30/51);(4)疗养体检无其他异常发现。结论健康特勤人员可出现S_ⅠS_ⅡS_Ⅲ综合征,多见于瘦长体型年轻人,可能系正常心电图变异,但诊断要慎重,须经心脏超声及X射线等检查排除器质性疾病。
简介:Neurotrophicfactorscompriseessentialsecretedproteinsthathaveseveralfunctionsinneuralandnon-neuraltissues,mediatingthedevelopment,survivalandmaintenanceofperipheralandcentralnervoussystem.Therefore,neurotrophicfactorissuehasbeenextensivelyinvestigatedintothecontextofneurodegenerativediseases.Alzheimer'sdiseaseandParkinson'sdiseaseshowchangesintheregulationofspecificneurotrophicfactorsandtheirreceptors,whichappeartobecriticalforneuronaldegeneration.Indeed,neurotrophicfactorspreventcelldeathindegenerativeprocessesandcanenhancethegrowthandfunctionofaffectedneuronsinthesedisorders.Basedonrecentreports,thisreviewdiscussesthemainfindingsrelatedtotheneurotrophicfactorsupport–mainlybrain-derivedneurotrophicfactorandglialcellline-derivedneurotrophicfactor–inthesurvival,proliferationandmaturationofaffectedneuronsinAlzheimer'sdiseaseandParkinson'sdiseaseaswellastheirputativeapplicationasnewtherapeuticapproachforthesediseasesmanagement.
简介:ThisarticlereviewstheeffectivenessofintratympaniccorticosteroidsforvertigocontrolinM_eni_ere'sdiseaseat2-yearsfollow-upaccordingtotheguidelinesexpressedbytheAmericanAcademyofOtolaryngology-Head&NeckSurgery.DespitetheincreaseduseofintratympaniccorticosteroidsforvertigocontrolinM_eni_ere'sdiseasethereisdebateastotheireffectiveness,particularlycomparedtogentamicin.Evenso,afterjustasinglecourseofinjections,corticosteroidscanreliablyprovidecompletevertigocontrol(ClassA)at2-yearsinabout50%ofcasesasindicatedinarecentdouble-blindrandomizedcontrolledclinicaltrial(Pateletal.,2016).Buttheeffectivenessofintratympaniccorticosteroidstrulyincreaseswhentreatmentisprovided'as-needed',wherebycompletevertigocontrolisestablishedinupto91%ofcases.Onthebasisofavailableliterature,thereisgoodevidencetorecommendtheuseofintratympanicsteroidtreatmentforvertigocontrolinM_eni_ere'sdisease,butpatientsmustbemonitoredfornon-response.Therationalefortreatingpatientsas-neededandthepossiblereasonsforcorticosteroidnonresponsearediscussed.
简介:Pyrimidinederivativeshavebeenreportedasneuroprotectiveagentsusefulforthetreatmentofvariousneurodegenerativedisorders.Inthepresentstudy,severalpyrimidineanalogueshavebeenevaluatedasneuroprotectiveagentsinMorriswatermazemodel.Itwasobservedthatpyrimidinederivatives8–17considerablyimprovelearning,memory,andmovementdeficitsinanimalmodels.Biochemicalestimationsofbrainserumoftreatedanimalsrevealedsuppressionofoxidativeandnitrosativestress,acetylcholinesteraseactivity,andotherparameterswhichleadstoneurodegenerationofbrain.Ofallthepyrimidinederivatives,thiomorpholinederivative8andpiperazineethanolderivative17werefoundtobethemostactiveneuroprotectiveagentsandproducedeffectscomparabletostandarddrugrivastigmineintermsofbehavioral,biochemical,andmolecularaspects.
简介:Leber'scongenitalamaurosis(LCA)andrecentgenetherapyadvancementfortreatinginheritedretinopathieswereextensiveliteraturereviewedusingMEDLINE,PubMedandEMBASE.Adeno-associatedviralvectorswerethemostutilisedvectorsforoculargenetherapy.Conephotoreceptorcellsmightuseanalternatepathwaywhichwasnotreliantoftheretinalpigmentepithelium(RPE)derivedretinoidisomerohydrolase(RPE65)toaccessthe11-cisretinaldehydechromophore.Researcheffortsdedicatedontheprogressionofagene-basedtherapyforthetreatmentofLCA2.Suchgenetherapyapproacheswereextremelysuccessfulincanine,porcineandrodentLCA2models.TherecombinantAAV2.hRPE65v2adenoassociatedvectorcontainedtheRPE65cDNAandwasreplicationdeficient.ItsinvitroinjectionintargetcellsinducedRPE65proteinproduction.Thegenetherapytrialsthatweresofarconductedforinheritedretinopathieshavegeneratedpromisingresults.PhaseIclinicaltrialstocureLCAandchoroideremiademonstratedthatadeno-associatedviralvectorscontainingRPEgenesandphotoreceptorsrespectively,couldbesuccessfullyadministeredtoinheritedretinopathypatients.AphaseIIItrialispresentlyongoingandifsuccessful,itwillleadthewaytoadditionalgenetherapyattemptstocuremonogenic,inheritedretinopathies.
简介:Cancerisamajorhealthconcernandleadingburdenoneconomyworldwide.Anincreasingeffortisdevotedtoisolationanddevelopmentofplant-deriveddietarycomponentsaseffectivechemo-preventiveproducts.Phytochemicalcompoundsfromnaturalresourcessuchasfruitsandvegetablesareresponsiblefordecreasingtheriskofcertaincancersamongtheconsumingpopulations.Apigenin,aflavonoidphytochemicalfoundinmanykindsoffruitsandvegetables,hasbeenshowntoexertsignificantbiologicaleffects,suchasanti-oxidant,anti-inflammatoryandmostparticularlyanti-neoplasticproperties.Thisreviewisintendedtosummarizethemostrecentadvancesintheanti-proliferativeandchemo-preventiveeffectsofapigeninindifferentcancermodels.Analysisofthedatafromthestudiedcancermodelshasrevealedthatapigeninexertsitsanti-proliferativeeffectsthroughmultipleandcomplexpathways.Thisguidedustodiscoversomecontroversialresultsabouttheexactroleofcertainmolecularpathwayssuchasautophagyintheanticancereffectsofapigenin.Further,therewerecumulativepositiveevidencessupportingtheinvolvementofcertainpathwayssuchasapoptosis,ROSandDNAdamageandrepair.Apigeninpossessesahighpotentialtobeusedasachemosensitizingagentthroughtheup-regulationofDR5pathway.Accordingtothesepreclinicalfindingswerecommendthatfurtherrobustunbiasedstudiesshouldconsiderthepossibleinteractionsbetweendifferentmolecularpathways.
简介:摘要目的针对5S管理模式在护理管理中的应用效果进行研究。方法我院从2016年1月-2017年1月,开始将5S管理模式引入护理管理,与实施前1年对比其应用效果。按照计划实施5S管理模式,对比其实施前后的物品放置情况、病区环境检查、一般差错情况以及护理满意度等。结果实施后5S管理模式后,病区环境检查评分以及满意度评分明显提高,差异显著(P<0.05)。实施前,物品随意放置率以及一般差错率分别为8.26%和0.92%,实施后,物品随意放置率(1.88%)以及一般差错率(0.24%)明显降低,差异显著(P<0.05)。结论5S管理模式能够降低物品随意放置率和一般差错率,提升护理满意度和病区环境,应用效果显著。
简介:摘要目的探讨科室创建“4S”护理服务,即“微笑(smile)服务”、“温暖(snug)服务”、“精细(scrupulousness)服务”、“满意(satisfaction)服务”对提高护理质量的作用。方法充分了解每一位患者的需求,使以往“自已实施什么护理,患者就接受什么护理的服务,变为“患者需要什么,我就护理什么”的服务,创建具有干部病房专科特点的“4S”特色护理服务品牌。比较实施“4S”特色护理前后患者对护士服务态度、技术熟练程度、基础护理质量、健康教育知晓等方面的满意率。结果实行“4S”护理服务前后比较,差异具有统计学意义(均p<0.05),具有可比性。结论科室开展“4S”特色护理服务,根据专科特点加以实施,深化了专科服务内涵,提升了患者满意度,创新了工作模式,提高了护理质量
简介:企业财务管理信息系统涉及到财务管理、行政和总务等每个方面的工作,同时与企业职工自身的利益密不可分。为了提高企业的工作信息化的水平和实现高等院校自身的管理效率,本文通过对企业财务管理工作中实际出现的问题提出解决的设计思路,将财务管理信息系统和企业信息化系统的内容相结合起来。企业财务管理信息系统更好地辅助学校的各项工作并做出正确的决策。本文通过用户管理模块、账务管理模块、学生收费模块、工资管理模块和员工信息管理模块这五个模块来更好地诠释企业财务管理信息系统的内容,系统采用SQLServer2008、C/S模式、B/S模式的相关技术,描述各系统的功能和信息,使财务管理信息系统更好的应用和服务于企业。