简介：Ourpreviousstudieshavehistomorphologicallyconfirmedthatnanofibrouspoly(3-hydroxybutyrateco-3-hydroxyvalerate)conduitcanbeusedtorepair30-mm-longsciaticnervedefects.However,therepaireffectsonratbehaviorsremainpoorlyunderstood.Inthisstudy,weusednanofibrouspoly(3-hydroxybutyrate-co-3-hydroxyvalerate)conduitandautologoussciaticnervetobridge30-mm-longratsciaticnervegaps.Within4monthsaftersurgery,ratsciaticnervefunctionalrecoverywasevaluatedpermonthbybehavioralanalyses,includingtoeoutangle,toespreadanalysis,walkingtrackanalysis,extensorposturalthrust,swimmingtest,open-fieldanalysisandnociceptivefunction.Resultsshowedthatratsciaticnervefunctionalrecoverywassimilarafternanofibrouspoly(3-hydroxybutyrate-co-3-hydroxyvalerate)conduitandautologousnervegrafting.Thesefindingssuggestthatnanofibrouspoly(3-hydroxybutyrate-co-3-hydroxyvalerate)conduitissuitableinuseforrepairoflong-segmentsciaticnervedefects.

简介：OBJECTIVE:Tosystematicallyevaluatethelong-termeffectandsafetyofXingnaoKaiqiaoneedlingmethodinischemicstroketreatment.DATARETRIEVAL:Weretrievedrelevantrandomandsemi-randomcontrolledtrialsthatusedtheXingnaoKaiqiaoneedlingmethodtotreatischemicstrokecomparedwithvariouscontroltreatmentssuchasconventionaldrugsorotheracupuncturetherapies.SearcheddatabasesincludedChinaNationalKnowledgeInfrastructure,WeipuInformationResourcesSystem,WanfangMedicalDataSystem,ChineseBiomedicalLiteratureDatabase,CochraneLibrary,andPubMed,fromMay2006toJuly2014.SELECTIONCRITERIA:Twoauthorsindependentlyconductedliteraturescreening,qualityevaluation,anddataextraction.ThequalityofarticleswasevaluatedaccordingtotheCochraneReviewers’Handbook5.1,andthestudywascarriedoutusingCochranesystemassessmentmethods.RevMan5.2wasusedformeta-analysisoftheincludedstudies.MAINOUTCOMEMEASURES:Mortalityrate,recurrencerate,anddisabilityratewereobserved.RESULTS:Ninerandomizedandsemi-randomizedcontrolledtrialstreating931casesofischemicstrokewereincludedinthisreview.Meta-analysisresultsshowedthattherewerenosignificantdifferencesinmortalityreduction(riskratio(RR)=0.58,95%confidenceinterval(CI):0.17–1.93,Z=0.89,P=0.37)orrecurrencerate(RR=0.55,95%CI:0.18–1.70,Z=1.04,P=0.30)ofischemicstrokepatientsbetweentheXingnaoKaiqiaoneedlingandcontroltreatmentgroups.However,theXingnaoKaiqiaoneedlingmethodhadatendencytowardshigherefficacyinmortalityreductionandrecurrencerates.TheXingnaoKaiqiaoneedlingmethodwassignificantlybetterthanthatofthecontroltreatmentinreducingdisabilityrate(RR=0.51,95%CI:0.27–0.98,Z=2.03,P<0.05).CONCLUSION:TheXingnaoKaiqiaoneedlingmethodhasabettereffectthancontroltreatmentinreducingdisabilityrate.Thelong-termeffectofXingnaoKaiqiaoneedlingagainstischemicstrokeisbetterthanthatofc

简介：Multipleregenerationofaxonalbudshasbeenshowntoexistduringtherepairofperipheralnerveinjury,whichconfirmsacertainrepairpotentialoftheinjuredperipheralnerve.Therefore,asystematicnervetranspositionrepairtechniquehasbeenproposedtotreatsevereperipheralnerveinjury.Duringnervetranspositionrepair,theregeneratednervefibersofmotorneuronsintheanteriorhornofthespinalcordcaneffectivelygrowintotherepaireddistalnerveandtargetmuscletissues,whichisconducivetotherecoveryofmotorfunction.Theaimofthisstudywastoexploreregenerationandnervefunctionalrecoveryafterrepairingalong-segmentperipheralnervedefectbytranspositionofdifferentdonornerves.Along-segment(2mm)ulnarnervedefectinSprague-Dawleyratswasrepairedbytranspositionofthemusculocutaneousnerve,medialpectoralnerve,muscularbranchesoftheradialnerveandanteriorinterosseousnerve(pronatorquadratusmusclebranch).Insiturepairoftheulnarnervewasconsideredasacontrol.Threemonthslater,wristflexionfunction,nerveregenerationandinnervationmusclerecoveryinratswereassessedusingneuroelectrophysiologicaltesting,osmicacidstainingandhematoxylin-eosinstaining,respectively.Ourfindingsindicatethatrepairofalong-segmentulnarnervedefectwithdifferentdonornervetranspositionscanreinnervateaxonalfunctionofmotorneuronsintheanteriorhornofspinalcordandrestorethefunctionofaffectedlimbstoacertainextent.