简介：Background:Depressiondisordercoexistsinchronicdiseaseswithsomaticdiseasesandhashighmorbidity,disabilityandmortality.Currentresearcheshaveconfirmedthatdepressionmaybecausedbycoronaryheartdisease,hypertensionandheartfailure.Meanwhile,cardiovasculardiseasesmaycauseorworsendepression,leadingtoprolongedhospitalizationandcomplications.

简介：SincePresidentObamaannouncedthePrecisionMedicineInitiativeintheUnitedStates,moreandmoreattentionhasbeenpaidtoprecisionmedicine.However,clinicianshavealreadyusedittotreatconditionssuchascancer.Manycardiovasculardiseaseshaveafamilialpresentation,andgeneticvariantsareassociatedwiththeprevention,diagnosis,andtreatmentofcardiovasculardiseases,whicharethebasisforprovidingprecisecaretopatientswithcardiovasculardiseases.Large-scalecohortsandmultiomicsarecriticalcomponentsofprecisionmedicine.Herewesummarizetheapplicationofprecisionmedicinetocardiovasculardiseasesbasedoncohortandomicstudies,andhopetoelicitdiscussionaboutfuturehealthcare.

简介：Inclinicalpractice,avarietyofsyndromesareassociatedwithcardiovasculardiseaseandhavecharacteristicfindings.Mostofthemareanautosomaldominantgeneticdisorderandhavedifferenttypesofcardiovascularabnormalities,includingelectrocardiographicconductiondefects,arrhythmias,cardiomyopathy,vascularandvalvulardiseases,cardiacseptaldefects,andpulmonaryproblems.Thereisagrowingneedforphysicianstopaymoreattentiontothesesyndromes.

简介：Atrialnatriureticpeptide(ANP)isapeptidehormonethathaspotentnatriuretic,diuretic,vasodilator,sympatholytic,andrenin-andaldos-terone-suppressingactivitiesandisinvolvedintheregulationofvolumeandelectrolytebalanceandbloodpressure.Further,ANPhasalsobeenshowntoinhibitcellulargrowth,proliferationandinduceapoptosisinavarietyofcelllines,includingvascularsmoothmusclecellsandcardiacmyocytes.RecentstudieshavedemonstratedthatANPisnotonlyinvolvedinbloodpressureandvolumehomeostasisbutalsointhedirectregulationofcardiacgrowth.Weandotherinvestigatorshavedemonstratedtheexistenceofnatriureticpeptidereceptorsintheheartandcardiaccells,suggestingthatANPhasdirectactionsoncardiactissue.SeveralrecentinvivostudieshavesuggestedthatstatementofANPisinverselyrelatedtocardiacgrowth/hypertrophy.TransgenicmiceoverexpressingANPhavelowerheartweightandbloodpressurethanwildtypemice.Conversely,we

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简介：The2016revisionofthe“ChineseGuidelinesonPreventionandTreatmentofDyslipidemiainAdults”istheoutcomeofthejointeffortsofthemembersofanexpertpanelformorethan1year,andisbasedonthe2007guidelines.Thereisnodoubtthatthereleaseofthe2007guidelinesgreatlyfacilitatedthemanagementofdyslipidemiaandthepreventionandtreatmentofatheroscleroticcardiovasculardiseases(ASCVDs)inChina.However,anupdateoftheguidelinesforthemanagementofdyslipidemiainChineseadultsisurgentlyneededsincehugechangeshaveoccurredintheconceptsofdyslipidemiaresearchandcontrolduringthelastdecade.

简介：Theuseofspeckle-trackingechocardiography(STE)isbecominganincreasinglyusefultoolintheevaluationofmyocardialdisease.STEsoftwarecantrackthemotionofthespecularpatterncreatedbytheinterferenceofultrasoundwiththemyofibersoftheheartandprovideaquantitativemeanstoevaluatesubtlechangesinventricularfunctionthatoftenoccurbeforechangesinventricularejectionfractionareobserved.STEismostoftenusedtomeasurethechangeinshape(strain)ofmyocardialsegmentsinthecircumferential,radial,andlongitudinaldirections.Invariousdiseases,includingcoronaryarterydisease,aorticstenosis,andmitralregurgitation,deficitsinlongitudinalstrainappeartooccurearlierthandeficitsinothermeasuresofstrainorinejectionfraction.ConsiderationofSTEmeasuresofleftventricularcontractionhasthepotentialtosignificantlyaffectclinicalmanagementandoutcomesofischemicandvalvularheartdiseasegiventheabilitytoseparatethosewithasymptomaticdiseasewhomaybenefitfromearlierinterventionsthancurrentguidelinesmaysuggest.