简介:Usingfourβ-cyclodextrinderivatives,2,6-di-O-benzyl-3-O-heptanonyl-β-CD,2,6-di-O-benzyl-3-O-octanonyl-β-CD,2,3-di-O-benzyl-6-O-heptanonyl-β-CD,and2,3-di-O-benzyl-6-O-octanonyl-β-CD,aschiralstationaryphasesofcapillarygaschromatography(CGC),theenantiomersofSharplessepoxideswerewellseparated.Theenantiomerexcessvalues(e.e.%)ofsomechiralSharplessepoxideswerealsodeterminedsuccessfullyusingtheseCDs.
简介:Anovelseriesofpyrido[1,2-e]purin-4(3H)-onederivativescontainingpolarsubstituentson5'-positionweredesignedandpreparedaspotentialPDE5inhibitors.Thispaperreportsthesyntheticroutes,1H-NMRdata,andthePDE5inhibitoryactivitiesofthetargetcompounds.Thepolarpiperazinylgroupcontained(on5'-position)compound,3B2,showedthehighestactivityamongthetestedderivativesbutlesspotencythansildenafil1.
简介:Startedfrom5-hydroxy-2-pentanone,(R)(E)-3,7-dimethyl-2-octene-1,8-dioicacid,callosobruchusicacid,wassynthesizedviafivestepswithD-(-)-camphorsultamasthechiralauxiliary.Itwasofgoodopticalpurityandyield.
简介:为了更好地研究牙龈卟啉菌(Prophyromonasgingivalis,Pg)表面蛋白(Surface-associatedproteins,SAP)的生物活性,实验用SAP体外刺激小鼠颅骨和人外周血单个核细胞,分别用自动生化分析仪和放免方法检测培养液中Ca2+和IL-6的含量.同时,采用ELISA和MTT法分别测定SAP免疫小鼠的抗体效价和诱导的脾细胞转化程度.结果显示:一方面SAP是体外诱导骨吸收和前炎性因子合成的介质;另一方面SAP免疫的小鼠产生了抗SAP特异性抗体和脾细胞特异增生反应.这说明具有生物活性的SAP诱导了实验小鼠产生体液免疫应答和细胞免疫应答.