简介：Acanthamoebaarefree-livingprotozoaorganismsthatliveabroadinnature.PathogenicAcanthamoebacancauseafatalgranulomatousamoebicencephalitisandkeratitis.SomespeciesofAcanthamoebacaninducesometumorcellsapoptosisinvitro.Prom1996wehaveprovedthatAcanthamoebaLstrain(A.lugdunensis-A.quina),firstlygotbyusfromkeratitispatientsinChina,couldinducetumorcells'apoptosis,includingPC12,B16cellsetal.InthisresearchweprovedthatboththebodyandthelysisofAcanthamoebacouldinducemousemelanomaB16cellsapoptosis.Buttheapoptosismechanismwaspoorlyunderstood.
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