简介：

简介：Inthepresentstudyexpressionofestrogenreceptorsubtype-α(ERα)and-β(ERβ)inthecerebralcortex,cerebellum,andolfactorybulbwasinvestigatedandcomparedbetweenneonatal(1～3-days-old)andadult(250～350g)rats,usingreversetranscription-polymerasechainreaction(RT-PCR).NoERαtranscriptsweredetectableintheadultcerebellumandolfactorybulb,whereasveryweakexpressionofERαwaspresentintheadultcerebralcortex.NosignificantdifferenceinERβtranscriptswasdetectablebetweentheneonatalandadultrats.WhiletranscriptsforbothERsubtypeswereco-expressedinthesebrainareasofneonatalrats,althoughERαexpressionwassignificantlyweakerthanERβ.EveninthecerebralcortexknowntocontainbothERsubtypesinadultrats,ERαtranscriptsinneonatalratsweremuchhigherthaninadult.TheseobservationsprovideevidencefortheexistenceofdifferentexpressionpatternsofERα/ERβtranscriptsinthesethreebrainareasbetweentheneonatalandadultrats,suggestingthateachERsubtypemayplayadistinctroleintheregulationofdifferentiation,development,andfunctionsofthebrainbyestrogen.