简介：Arraycomparativegenomichybridization(CGH)hasbeenpopularlyusedforanalyzingDNAcopynumbervariationsindiseaseslikecancer.Inthisstudy,weinvestigated82sporadicsamplesfrom49breastcancerpatientsusing1-MbresolutionbacterialartificialchromosomeCGHarrays.Anumberofhighlyfrequentgenomicaberrationswerediscovered,whichmayactas'drivers'oftumorprogression.Meanwhile,thegenomicprofilesoffour'normal'breasttissuesamplestakenatleast2cmawayfromtheprimarytumorsiteswerealsofoundtohavesomegenomicaberrationsthatrecurredwithhighfrequencyintheprimarytumors,whichmayhaveimportantimplicationsforclinicaltherapy.Additionally,weperformedclasscomparisonandclasspredictionforvariousclinicopathologicalparameters,andalistofcharacteristicgenomicaberrationsassociatedwithdifferentclinicopathologicalphenotypeswascompiled.Ourstudyprovidescluesforfurtherinvestigationsoftheunderlyingmechanismsofbreastcarcinogenesis.