简介:DNAtetrahedralnanostructuresareconsideredtobenewnanocarriersbecausetheycanbepreciselycontrolledandholdexcellentpenetrationabilitytothecellularmembrane.AlthoughtheDNAtetrahedralnanostructureisextensivelystudiedinbiologyandmedicine,itsbehaviorinthecellswithnanoscaleresolutionisnotunderstoodclearly.Inthisletter,wedemonstratesuperresolutionfluorescenceimagingofthedistributionofDNAtetrahedralnanostructuresinthecellwithasimulatedemissiondepletion(STED)microscope,whichisbuiltbasedonaconventionalconfocalmicroscopeandcanprovidearesolutionof70nm.