简介：摘要目的近年由于辅助生育技术的不断发展成熟,促排卵药物的临床应用,国家计划生育政策的变动高龄产妇的增加,多胎妊娠逐年增多,双胎中以单绒毛膜双胎并发症多见,双胎之一选择性胎儿生长受限(sFGR)是其特殊的并发症之一,常引起胎儿宫内死亡及新生儿严重并发症和死亡.本文探讨单绒毛膜双羊膜囊双胎妊娠(MCDA),选择性胎儿生长受限的产前超声监测方法对诊断及治疗选择的价值.方法选取我院２０１３年５月至２０１５年５月从早孕开始在我院健卡,并诊断为单绒毛膜双羊膜囊的双胎的胎儿开始进行产前超声监测,并从中诊断６例选择性生长受限的胎儿病例,进行相应的分期、分型和监测随访至妊娠终止.结果６例sFGR,２０周前诊断１例,２０周—２９周诊断５例.其中sFGRⅠ型２例,３４周－３５周行剖宫产结束妊娠后大胎/小胎均存活.Ⅱ型３例,２例中小胎均出现静脉导管A波倒置或缺失,大脑中动脉PI值降低,这２例胎儿孕周３０周－３３周行剖宫产结束妊娠后大胎/小胎均存活,另１例因孕周较小２４周,超声检查时小胎已经死亡,相隔８小时后超声再次检查大胎也胎死宫内.Ⅲ型１例３４周行剖宫产结束妊娠后大胎/小胎均存活.结论早孕期诊断双胎妊娠的绒毛膜性具有重要的临床意义,早期诊断MCDA胎儿合并sFGR,并定期监测脐动脉、大脑中动脉、静脉导管血流,其中静脉导管异常是预测胎儿情况恶化的可靠指标.sFGR在超声严密的监测下选择分娩时机,可提高MCDA围生儿的生存率,且存活的胎儿出生后大多预后良好.关键词单绒毛膜双羊膜囊双胎;生长受限;超声;监测;诊断;治疗选择AbstractObjectiveInrecentyears,duetothecontinuousdevelopmentofassistedreproductivetechnology,theclinicalapplicationofovulationinductionmedicine,changesinthenationalone－childpolicyandtheincreaseofelderlyparturientwomen,themultiplepregnancyhasincreasedeveryyear,andthecompliＧcationofmonochorionicdiamnioticisverycommonintwins,whiletheselectivefetalgrowthrestriction(sFGR)isoneofthespecialcomplications,whichoftencausesintrauterinefetaldeathandneonatalseverecomplicationsanddeath．Thepaperdiscussesthevalueofprenatalultrasoundmonitoringinthediagnosisandtreatmentoptionofmonochorionicdiamniotic(MCDA)twinswithselectiveintrauterinegrowthrestriction．MethodsSelectthetwins’fetusthatarediagnosedasmonochorionicdiamniotic,establishingthehealthcardfromearlypregnancyinourhospitalfromMay２０１３toMay２０１５,toperformprenatalultrasoundmonitoＧring,andthenselectsixcasesdiagnosedasselectivityfetalgrowthrestrictiontoconductcorrespondingperiodization,classification,monitoringandfollow－uptotheterminationofpregnancy．ResultsOneofthesixcasesofsFGRwasdiagnosedbefore２０weeks,andtheotherfivewerediagnosedform２０to２９weeks．Thereare２casesofsFGRTypeIandboththebig/smallfetussurvivedaftertheendofpregnancybyperformingcaesareansectionsfrom３４to３５weeks．Thereare３caＧsesofsFGRTypeII,inwhich２caseswerefoundvenouscatheterAwaveinversionordeletionanddeclineofPIvalueinmiddlecerebralartery,boththebig/smallfetusofthesetwocasesweresurvivedaftertheendofpregnancybyperformingcaesareansectionsfrom３０to３３weeks;theothercaseissmallerof２４gesＧtationalweeks,thesmallfetalwasfounddiedwhenperformingtheultrasound,andthebigonewasfounddiedinuterowhenperformingtheultrasoundafter８hours．ThelastcaseisofsFGRTypeIIIandboththebig/smallfetussurvivedaftertheendofpregnancybyperformingcaesareansectionsin３４weeks．ConcluＧsionThediagnosisofchorionoftwinpregnancyinearlypregnancyisofimportantclinicalsignificance．ConductearlydiagnosisofMCDAtwinswithsFGRandreguＧlarmonitoringoftheumbilicalartery,middlecerebralartery,venouscatheterbloodstream,inwhichtheabnormalityofvenouscatheterisareliableindicatoroffetaldeterioration．SelectingthedeliverytimeofsFGRbytheclosemonitoringofultrasoundcanimprovethesurvivalrateofMCDAperinatalinfant,andtheprogＧnosisofmostsurvivalfetusisgoodKeywordsMonochorionicdiamniotic(MCDA)twins;Growthretardation;Ultrasound;Monitoring;Diagnosis;Treatmentoptions中图分类号R７３５．３文献标识码B文章编号１００１－５３０２(２０１５)０９－０６２６－０２