摘要
Objective:Preparecross-linkedHAgelswithhighermechanicalstability,lowerdegradationvelocityanddesirablebiocompatibility,soastoextendtheusageofHA.Method:1.TestmolecularweightofHA(MrHA)byviscosimetry;2.Preparecross-linkedHAgelsbyDVS,GTA,DEC;3.Discussthecross-linkinganddegradationprocedure;4,evaluatethebiocompatibilityofthebestHAgels.Results:ThemechanicalstabilityanddurabilitytodegradationofHA-DVSgelsaresuperiortothoseofothergels,andwhenHA:DVS=40:1(g/g),at35℃andin0.2MNaOHsolution,theHA-DVSgelshowsthebestmechanicalstability,anditscytotoxicityreachesclassI,hemolysisratioislowerthan5%.Conclusion:OurHADVSgelcanbeusedtopreparebiologicscaffolds.
出版日期
2006年04月14日(中国期刊网平台首次上网日期,不代表论文的发表时间)