摘要
Tinnitusisasubjectiveperceptionofphantomsoundthatcurrentlycannotbeobjectivelymeasured.However,thereisgrowingevidencesuggestingthatthebiologicalsourceoftinnitusmayexistinoneormorethanoneplaceintheauditorypathway.Recentstudieshavefoundthatneurotransmittersormodulators,suchasglutamate,γ-aminobutyricacid(GABA),serotonin,dynorphin,dopamine,neurosteroid,acetylcholine(ACh)andsubstanceP,areinvolvedintinnitusgeneration.Animalandhumanstudieshaveshownthatsomeoftheseneurotransmittersandtheagonistsorantagonistsoftheirreceptorseitheraffecttinnitusbehaviorsordemonstratesomedegreeoftreatmenteffectsontinnitus.However,duetotheunclearbiologicalmechanismsoftinnitusandsideeffectsofthesedrugs,thevalueofclinicalusageofsuchdrugsintreatingtinnitusisyettobeestablished.Revealingtherelationshipbetweentinnitusandneurotransmitterreceptorfunctionswillhelpidentifymoreeffectivedrugsfortinnitustreatment.Thisarticlereviewstheliteratureofneurophysiologicalstudiesontinnitusinbothanimalandhumansubjectstudiesatvariouslevelsoftheauditorypathway.
出版日期
2007年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
