摘要
Styreneisextensivelyusedinindustry,butitsototoxicity,inparticularinthepregnantfemaleandtheoffspring,isstillnotwellunderstood.Inthecurrentstudy,youngadultmaleratsandpregnantfemaleratswereexposedtostyrenebygavageatdifferentdoses.Theyoungadultmaleratsreceivedatotalof12g/kgstyrenewithindifferentperiods(800mg/kg/dayfor5days/weekfor3weeks,400mg/kg/dayfor5days/weekfor6weeks,200mg/kg/dayfor5days/weekfor12weeks,and100mg/kg/dayfor5days/weekfor24weeks)andthepregnantfemaleratsreceivedstyreneatadoseof400mg/kg/dayfor5days/weekfor6weeksstartingfromthegestationday-4.Hearinglossandhaircelllosswereassessed5daysafterthestyrenetreatmentintheyoungadultmaleratsandinthemotherrats.Thecochlearimpairmentsintheratpupswereexamined2monthsaftertheirbirth.Thestyreneexposurecausedhearinglossandhaircelllossstartingfromthemid-frequencyregioninthethirdrowofouterhaircells(OHCs)andtheimpairmentsappearedtoberelatedtothedosinglevelineachsingleday.Significantly,thestyreneexposuretothepregnantratsinterferedwithauditoryfunctionaldevelopmentoftheirfetus,leadingtoadeficitofcochlearamplification,althoughtheOHCsappearedtodevelopwell.Theresultsindicatethatashort-termhigh-levelstyreneexposuremaybemoreototoxicthanalong-termlow-levelexposureforasimilartotalstyrenedoseandthestyreneinthepregnantwoman'sbodymayinterferewithauditorydevelopmentoftheirfetus.
出版日期
2011年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
