摘要
BACKGROUND:Pattern-visualevokedpotential(PVEP)canreflectthefunctionalstatusofretinalganglialcells(RGC)andvisualcortex,andisanobjectiveexaminationforvisualpathwayfunction.Itisauniquemethodforobjectivelyexaminingtheopticnervefunctionofopticganglioncells.OBJECTIVE:Toobservetheeffectsofnervegrowthfactor(NGF)onPVEFinthetreatmentofopticnervecontusion,evaluatetheclinicalefficacyofNGF,andmakeanefficacycomparisonwithvitaminB12.DESIGN:Arandomlygrouping,controlledobservation.SETTING:DepartmentofOphthalmology,TangshanGongrenHospitalAffiliatedtoHebeiMedicalUniversity.PARTICIPANTS:Fortypatientswithopticnervecontusioncausedbyeyetrauma,whoreceivedthetreatmentintheTangshanWorkerHospitalAffiliatedtoHebeiMedicalUniversitybetweenJanuary2006andJune2007,wererecruitedinthisstudy.Theinvolved40patients,including34malesand6females,wereaged14-59years.TheywereconfirmedtohaveopticnervecontusionbyophthalmologicconsultationcombinedwithhistoryofdiseaseandorbitalCTexamination.Informedconsentsoftreatmentsanddetecteditemswereobtainedfromallthepatients.Thepatientswererandomlydividedinto2groupswith20ineach:NGFgroupandvitaminB12group.METHODS:Conservativetreatmentwasusedinthetwogroups.Inaddition,patientsintheNGFgroupwereintramuscularlyinjectedwithNGFsolution18μg/time,onceaday.ThoseinthevitaminB12groupwereinjectedbythesamemethodwithcommonvitaminB12of500μgcombinedwithvitaminB1of100mg,onceaday.MAINOUTCOMEMEASURES:PVEPexaminationwasconductedinallthepatientsbefore,oneandtwoweeksaftertreatment,andlatencyandamplitudeatP100weredetected.RESULTS:Fortypatientswithopticnervecontusionparticipatedinthefinalanalysis.Beforetreatment,significantdifferencesinthelatencyandamplitudeatP100werenotfoundinpatientsbetweentwogroups(P>0.05).ForeachpatientintheNGF
出版日期
2007年09月19日（中国期刊网平台首次上网日期，不代表论文的发表时间）
