摘要
Wehaveappliedconceptsfrominformationtheoryforacomparativeanalysisofdonor(gt)andacceptor(ag)splicesiteregionsinthegenesoffivedifferentor-ganismsbycalculatingtheirmutualinformationcontent(relativeentropy)overaselectedblockofnucleotides.Asimilarpatternthattheinformationcontentdecreasesastheblocksizeincreaseswasobservedforbothregionsinalltheorgan-ismsstudied.Thisresultsuggeststhattheinformationrequiredforsplicingmightbecontainedintheconsensusof～6-8ntatbothregions.Weassumefromourstudythateventhoughthenucleotidesareshowingsomedegreesofconservationintheflankingregionsofthesplicesites,certainlevelofvariabilityisstilltolerated,whichleadsthesplicingprocesstooccurnormallyeveniftheextentofbasepairingisnotfullysatisfied.Wealsosuggestthatthisvariabilitycanbecompensatedbyrecognizingdifferentsplicesiteswithdifferentspliceosomalfactors.
出版日期
2006年04月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）
