Approaches to post-testicular contraception

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摘要 Theinductionofinfertilityinmalesofseveralspeciesthroughepididymalinterferenceismoredifficulttoachievebyreductionoftheamountsofepididymalsecretions(ega-glucosidase,L-camifine)orimmunologicalinterferencewithsecretedproteins(egD/E,P34H,P26h)thanbydirectactionsofdrugsonspermfunction(eginhibitionofglyceraldehyde3-phosphatedehydrogenasebychloro-compounds).Thelatterapproachholdspromiseformankindashumanspelmaresusceptibletoglycolyticinhibition.Futurecontraceptivedevelopmentsmayarisefromproductionoftargetedinhibitors,researchonthedisplacementofspermproteinsintheepididymisandinterferencewithspermplasmamembraneionchannels.(As/anJAndrof1999Jun;1:29-36)
机构地区 不详
出版日期 1999年01月11日(中国期刊网平台首次上网日期,不代表论文的发表时间)
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