摘要
Catheterablationofpersistentatrialfibrillation(AF)remainsachallengingtask.Thelong-termclini-caloutcomeandpredictorsfortherecurrenceofatrialarrhythmiasafterablationhasnotbeenconsistent.MethodsWeanalyzedtheclinicaloutcomeof103consecutivepatientswithafollow-up>12monthswhounderwentcatheterablationforpersistentAF.Westudiedtheirclinicaldataintermsofage,AFduration,concomitantdieases(hypertension,dia-betesormitralinsuffciency),leftatrialdiameter,catheterablationstrategies(circumferentialpulmonaryveinablation,complexablation)andthefollow-uprhythm.COXproportionalhazardmultivariateregressionanalysiswasperformedtoidentifythepredictorsofrecurrentatrialarrhythmiasafterablation.ResultsTherewere85malesand18femaleswithameanageof55.5±11.9yearsold.Afterafollowing-upof26.7±13.8months(12-61),89patients(86.4%)remainedsinusrhythm(SR),including67(65.0%)undergoingsingleprocedure,2(1.9%)withrecurrentatrialtachycardia(AT)undergoingsuccessfulcardioversionbydrug(amiodarone),and20undergoingre-ablation.Fourteenfailurecasesincluded8unsuccessfulpatientswithchronicAFwhorefusedre-ablation,5failurecasesafterre-ablationand1remainingAFaftersurgicalablation.Thesuccessfulrateofrepeatprocedurewas76.9%(20/26).COXregressionanalysisindicatedthatthepredictorsforrecurrencewerehypertension(OR=8.251,P=0.024),1AFdura-tion(OR=1.108,P=0.013),andmitralinsufficiency(OR=8.982,P=0.009).Complexablationstrategy(cir-cumferentialpulmonaryveinablation+lineablation+CFAE+linearablationalongtheatrialsideofcoronarysinus)decreasedtheriskofrecurrence(OR=0.004,P=0.009).ConclusionsSuccessfulrateofablationforpersistentAFafterthefirst12monthswashigh.Repeatprocedurecouldfurtherimprovethesinusrate.Hypertension,AFdurationandmitralinsuffciencywereindependentpredictorsofrecurrentatrialarrhythmiasafterpersisten
出版日期
2010年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
