摘要
Adiponectin(APN),anadipokineproducedbyadipocytes,hasbeenshowntohaveacriticalroleinthepathogenesisofobesityassociatedmalignancies.Throughitsreceptorinteractions,APNmayexertitsanti-carcinogeniceffectsincludingregulatingcellsurvival,apoptosisandmetastasisviaaplethoraofsignallingpathways.Despitethestrongevidencesupportingthisnotion,someworkmayindicateotherwise.Ourreviewaddressesallcontroversiescritically.Onthewhole,hypoadiponectinaemiaisassociatedwithincreasedriskofseveralmalignanciesandpoorprognosis.Inaddition,variousgeneticpolymorphismsmaypredisposeindividualstoincreasedriskofobesity-associatedmalignancies.WealsoprovideanupdatedsummaryontherapeuticinterventionstoincreaseAPNlevelsthatareofkeyinterestinthisfield.TodateeffortstomanipulateAPNlevelshavebeenpromising,butmuchworkremainstobedone.
出版日期
2016年01月11日（中国期刊网平台首次上网日期，不代表论文的发表时间）
