Substance P combined with epidermal stem cells promotes wound healing and nerve regeneration in diabetes mellitus-中国期刊网

摘要 ExogenoussubstancePaccelerateswoundhealingindiabetes,butthemechanismremainspoorlyunderstood.Here,weestablishedaratmodelbyintraperitoneallyinjectingstreptozotocin.Fourwounds(1.8cmdiameter)weredrilledusingaself-madepunchontotheback,bilateraltothevertebralcolumn,andthentreatedusingamnioticmembranewithepidermalstemcellsand/orsubstanceParoundandinthemiddleofthewounds.Withthecombinedtreatmentthewound-healingratewas100%at14days.Withprolongedtime,typeIcollagencontentgraduallyincreased,yettypeIIIcollagencontentgraduallydiminished.Abundantproteingeneproduct9.5-andsubstanceP-immunoreactivenervefibersregenerated.Partialnervefiberendingsextendedtotheepidermis.ThetherapeuticeffectsofcombinedsubstancePandepidermalstemcellswerebetterthanwithamnioticmembraneandeitherfactoralone.OurresultssuggestthatthecombinationofsubstancePandepidermalstemcellseffectivelycontributestonerveregenerationandwoundhealingindiabeticrats.

1赖西南;王正国;魏立;王丽丽. Effect of substance P released from peripheral nerve ending on endogenous expression of epidermal growth factor and its receptor in wound healing.临床医学,2002-03.
2Meihua Zhang,Munan Ma,Jinping Wang,Yijun Wang,Xinrui Yang,Songtao Fu. Effect of Gestational Diabetes Mellitus on the Growth, Development, and Stem Cells of Offspring.医药卫生,2023-03.
3Zhen Zhang;Shouyu Wang;Xiliang Tian;Zexu Zhao;Jianing Zhang;Decheng Lv. Maggot homogenate is associated with neural regeneration and wound healing in the rat.神经病学与精神病学,2010-08.
4Hu Xiao;Dechang Wang;Ran Huo;Yibing Wang;Yongqiang Feng;Qiang Li. Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression.神经病学与精神病学,2013-12.
5Bo Xiao;Feng Rao;Zhi-yuan Guo;Xun Sun;Yi-guo Wang;Shu-yun Liu;Ai-yuan Wang;Quan-yi Guo;Hao-ye Meng;Qing Zhao;Jiang Peng;Yu Wang;Shi-bi Lu. Extracellular matrix from human umbilical cordderived mesenchymal stem cells as a scaffold for peripheral nerve regeneration.神经病学与精神病学,2016-07.
6Jin-Ling MA;Jeroen J. J. P. van den BEUCKEN;Ju-Li PAN;Fu-Zhai CUI;Su CHEN. Bone regeneration using coculture of mesenchymal stem cells and angiogenic cells.材料科学与工程,2014-01.
7张翠萍;付小兵. Therapeutic potential of stem cells in skin repair and regeneration.临床医学,2008-04.
8Ludovica Parisi;Edoardo Manfredi. Applicability of tooth derived stem cells in neural regeneration.神经病学与精神病学,2016-11.
9ZHAO Fengyi ZHOU Peilan WANG Ruilin YANG Mingfu ZHAO Weisheng WEI Dian ZHANG Tieliang YAO Kangde CUI Yuanlu. A study on peripheral nerve regeneration via biomimetic conduits loaded with Schwann cells and nerve growth factor.生物医学工程,2001-02.
10Na Liu,Yun Xie,Yonghuan Zhen,Yujia Shang,GuanhuiEr Wang,Lingjuan Zhu,Yang An. Free-cell therapeutics and mechanism of exosomes from adipose-derived stem cells in promoting wound healing: current understanding and future applications.医药卫生,2022-12.

Substance P combined with epidermal stem cells promotes wound healing and nerve regeneration in diabetes mellitus

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Substance P combined with epidermal stem cells promotes wound healing and nerve regeneration in diabetes mellitus

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