摘要
Biologicalelementsusuallyexerttheirfunctionsthroughinteractionswithotherstoformvarioustypesofbiologicalnetworks.Theabilityofcontrollingthedynamicsofbiologicalnetworksisofenormousbenefitstopharmaceuticalandmedicalindustryaswellasscientificresearch.Thoughtherearemanymathematicalmethodsforsteeringdynamicsystemstowardsdesiredstates,themethodsareusuallynotfeasibleforapplyingtocomplexbiologicalnetworks.Thedifficultiescomefromthelackofaccuratemodelthatcancapturethedynamicsofinteractionsbetweenbiologicalelementsandthefactthatmanymathematicalmethodsarecomputationallyintractableforlarge-scalenetworks.Recently,aconceptincontroltheory--controllability,hasbeenappliedtoinvestigatethedynamicsofcomplexnetworks.Inthisarticle,recentadvancesonthecontrollabilityofcomplexnetworksandapplicationstobiologicalnetworksarereviewed.Developingdynamicmodelsisthepriorconcernforanalyzingdynamicsofbiologicalnetworks.First,weintroduceawidelyuseddynamicmodelforinvestigatingcontrollabilityofcomplexnetworks.Thenrecentstudiesoftheoremsandalgorithmsforhavingcomplexbiologicalnetworkscontrollableingeneralorspecificapplicationscenariosarereviewed.Finally,applicationstorealbiologicalnetworksmanifestthatinvestigatingthecontrollabilityofbiologicalnetworkscanshedlightsonmanycriticalphysiologicalormedicalproblems,suchasrevealingbiologicalmechanismsandidentifyingdrugtargets,fromasystematicperspective.
出版日期
2019年01月11日（中国期刊网平台首次上网日期，不代表论文的发表时间）
