简介：PostedonJanuary4,2017byFDAVoiceThispastyearwasanothersuccessfulyearforthenewdrugsprograminFDA’sCenterforDrugEvaluationandResearch(CDER).CDERreviewedandapproved22noveldrugs,mostofwhichhavethepotentialtoaddsignificantclinicalvalue

简介：Pyrimidinederivativeshavebeenreportedasneuroprotectiveagentsusefulforthetreatmentofvariousneurodegenerativedisorders.Inthepresentstudy,severalpyrimidineanalogueshavebeenevaluatedasneuroprotectiveagentsinMorriswatermazemodel.Itwasobservedthatpyrimidinederivatives8–17considerablyimprovelearning,memory,andmovementdeficitsinanimalmodels.Biochemicalestimationsofbrainserumoftreatedanimalsrevealedsuppressionofoxidativeandnitrosativestress,acetylcholinesteraseactivity,andotherparameterswhichleadstoneurodegenerationofbrain.Ofallthepyrimidinederivatives,thiomorpholinederivative8andpiperazineethanolderivative17werefoundtobethemostactiveneuroprotectiveagentsandproducedeffectscomparabletostandarddrugrivastigmineintermsofbehavioral,biochemical,andmolecularaspects.

简介：目的探讨血清N末端脑钠肽前体（NT-proBNP）水平在小儿肺炎合并呼吸困难类型中的诊断意义。方法选择2014年8月—2015年8月河北省保定市第二中心医院收治的396例小儿肺炎中确诊为心源性呼吸困难40例,非心源性呼吸困难39例,另选择同期健康体检的40例作为对照组。对3组均进行血清NT-proBNP检测,观察3组血清NT-proBNP水平,分析心源性呼吸困难患儿血NT-proBNP水平与左心室射血分数（LVEF）间的相关性。结果小儿肺炎合并心源性呼吸困难组血清NT-proBNP水平高于非心源性呼吸困难组和对照组,差异有统计学意义（P〈0.05）。心源性呼吸困难组患儿血清NT-proBNP水平与LVEF呈负相关（r=-0.697,P〈0.05）。结论NT-proBNP可作为鉴别小儿心源性呼吸困难和肺源性呼吸困难的客观指标,其方法简单、迅速。

简介：阻塞性睡眠呼吸暂停综合征（OSAS）是一种成人常见疾病,儿童的发病率为0.7%~2.9%。其症状儿童不如成人典型,可表现为发育缓慢、多动以及学习和认知障碍。