The polygenic risk in schizophrenia: assessing GWASs and evaluating Clozapine, ECT and other treatment modalities

(整期优先)网络出版时间:2019-01-11
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Researchshowsthatthemortalityrateamongpeoplewithschizophreniaisuptofourtimeshigherthanthatinthegeneralpopulation.Thesubsequenthighcomorbiditiesandsocietalcostofschizophrenianecessitatefindingbetter,moreeffectivetreatmentsandstrategiesforprevention.Oneofthecurrentobstaclesarethecomplicatedgeneetiologiesthatareinvolvedinthepathophyslologyofschizophrenia.Sofar,anincreasingnumberofclinicalandexperimentalstudiesshowlinksbetweenschizophreniatreatmentandgeneticconditions.Here,weanalyzetheliteratureonschizophreniagenetics,withaparticularfocusonthebrain,themindandenvironmentalinsults.Anoverlapofschlzophrenlawithotherpsychoticdisordershasalsobeentakenintoaccuntwithanattempttofindaparallelrelationshipbetweengeneticsandtreatment.Finally,wesummarizeallthepresent-daytreatmentoptionsforschizophrenialikeclozapineandelectroconvulslvetherapyandalsotakeintoconsiderationtherelativelyunexploredroleoftraditionalChinesemedicine.