A Genome Sequence of Novel SARS-CoV Isolates： the Genotype,GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China-中国期刊网

摘要 Wereportacompletegenomicsequenceofrareisolates(minorgenotype)oftheSARS-CoVfromSARSpatientsinGuangdong,China,wherethefirstfewcasesemerged.Themoststrikingdiscoveryfromtheisolateisanextra29-nucleotidesequencelocatedatthenucleotidepositionsbetween27,863and27,864(referredtothecompletesequenceofBJ01)withinanoverlappedregioncomposedofBGI-PUP5(BGI-postulateduncharacterizedprotein5)andBGI-PUP6upstreamoftheN(nucleocapsid)protein.Thediscoveryofthisminorgenotype,GD-Ins29,suggestsasignificantgeneticeventanddifferentiatesitfromthepreviouslyre-portedgenotype,thedominantformamongallsequencedSARS-CoVisolates.A17-ntsegmentofthisextrasequenceisidenticaltoasegmentofthesamesizeintwohumanmRNAsequencesthatmayinterferewithviralgenomereplicationandtranscriptioninthecytosoloftheinfectedcells.Itprovidesanewavenuefortheexplorationofthevirus-hostinteractioninviralevolution,hostpathogenesis,andvaccinedevelopment.

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A Genome Sequence of Novel SARS-CoV Isolates： the Genotype,GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China

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A Genome Sequence of Novel SARS-CoV Isolates： the Genotype,GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China

来源期刊

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