学科分类
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2 个结果
  • 简介:Ininsects,thegustatorysystemplaysacrucialroleinmultiplephysiologicalbehaviors,includingfeeding,toxinavoidance,courtship,matingandoviposition.Gustatorystimulifromtheenvironmentarerecognizedbygustatoryreceptors.Todate,littleisknownaboutthefunctionofgustatoryreceptorsinagriculturalpestinsects.Inthisstudy,weclonedasugargustatoryreceptorgene,N/Gr11,fromthebrownplanthopper(BPH),Nilaparvatalugens(Stal),aseriouspestofriceinAsia;wethenidentifieditsligands,namely,fructose,galactoseandarabinose,bycalciumimagingassay.AfterinjectionofN/Gr11doublestrandedRNA,wefoundthatthenumberofeggslaidbyBPHdecreased.Moreover,wefoundthatN/Gr11inhibitedthephosphorylationofadenosinemonophosphate-activatedproteinkinase(AMPK)andpromotedthephosphorylationofproteinkinaseB(AKT).ThesefindingsdemonstratedthatN/Gr11couldacceleratethefecundityofBPHthroughAMPK-andAKT-mediatedsignalingpathways.Thisisthefirstreporttoindicatethatagustatoryreceptormodulatesthefecundityofinsectsandthatthereceptorcouldbeapotentialtargetforpestcontrol.

  • 标签: brown PLANTHOPPER FECUNDITY GUSTATORY receptors LIGANDS
  • 简介:AbstractBackground:Smell and taste loss are highly prevalent symptoms in coronavirus disease 2019 (COVID-19), although few studies have employed objective measures to quantify these symptoms, especially dysgeusia. Reports of unrecognized anosmia in COVID-19 patients suggests that self-reported measures are insufficient for capturing patients with chemosensory dysfunction.Objectives:The purpose of this study was to quantify the impact of recent COVID-19 infection on chemosensory function and demonstrate the use of at-home objective smell and taste testing in an at-risk population of healthcare workers.Methods:Two hundred and fifty healthcare workers were screened for possible loss of smell and taste using online surveys. Self-administered smell and taste tests were mailed to respondents meeting criteria for elevated risk of infection, and one-month follow-up surveys were completed.Results:Among subjects with prior SARS-CoV-2 infection, 73% reported symptoms of olfactory and/or gustatory dysfunction. Self-reported smell and taste loss were both strong predictors of COVID-19 positivity. Subjects with evidence of recent SARS-CoV-2 infection (<45 days) had significantly lower olfactory scores but equivalent gustatory scores compared to other subjects. There was a time-dependent increase in smell scores but not in taste scores among subjects with prior infection and chemosensory symptoms. The overall infection rate was 4.4%, with 2.5% reported by PCR swab.Conclusion:Healthcare workers with recent SARS-CoV-2 infection had reduced olfaction and normal gustation on self-administered objective testing compared to those without infection. Rates of infection and chemosensory symptoms in our cohort of healthcare workers reflect those of the general public.

  • 标签: Anosmia Brief Smell Identification Test Chemosensory dysfunction COVID-19 Dysgeusia Gustation Healthcare workers Objective testing Olfaction Screening University of Pennsylvania Smell Identification Test