简介:ObjectivesToinvestigatetheassociationofsolubleFasligand(sFasL)andsolubleFasreceptor(sFas)withhumanchroniccongestiveheartfailure(CHF).MethodsTheserumlevelofsFasLandsFasin33patientswithCHF(13incardiacfunctionclassⅡ,17inclassⅢ,3inclassⅣ,NYHA)wasassessedwithenzyme-linkedimmunosorbentassay,andwascomparedwiththatof18age-,bloodpressure-matchedpatientswithcardiacfunctionclassⅠ(NYHA).ResultsTherewasnodifferenceinthelevelofsFasLbetweenthetwogroups[CHFgroup:231.50+/-84.50(cardiacfunctionclassⅡ216.50+/-96.00,classⅢ226.80+/-85.70,classⅣ244.00+/-73.00)vs.cardiacfunctionclassIgroup:217.50+/-89.00pg/mL,P>0.05].However,thelevelofsFaswassignificantlyhigherinthepatientswithCHFthanthoseofcardiacfunctionclassIgroup[CHFgroup:1353.30+/-507.71(cardiacfunctionclassⅡ1154.85+/-371.20,classⅢ1412.88+/-493.62,classⅣ1875.67+/-806.
简介:<正>Fasligand(FasL)wasfirstdescribedfunctionallyasaninduciblecellsurfacemoleculeusedbycytotoxicTcellstoinduceapoptoticcelldeathintumorcellsandactivatedlymphocytes.WiththeidentificationofFasastheIprgeneproduct,FasLbecamerecognizedasamoleculeinvolvedindown-regulationoftheimmunesystem.WhileFasLcanbeusedtoefficientlykillFas-expressingtumorcellsaswellasactivatedTandBlymphocytesinvitro,attemptstouseFasLtherapeuticallytotreatcancerortopreventtransplant
简介:摘要:曲线梁桥能很好地适用地形、地物的限制,而且其结构线条平顺、流畅、明快,给人以美的享受。在公路建设中,除特大桥梁外,一般要求桥梁地平面布置服从公路线形,在进行平、纵、断三方面综合设计时,应做到平面流畅、纵坡均衡、横断面合理,并避免长直线设计。此时,曲线梁桥往往成为最优方案。预应力混凝土连续曲线梁桥在使用过程中。甚至在其施工的过程当中,会由于设计的不合理以及周围环境的影响,曲线梁桥的梁体可能会出现沿着径向的位移和向梁体外侧的翻转即曲线梁桥的偏位问题。它具体表现在梁体的应力重分布,支座的竖向与横向支反力以及对桥墩应力的改变。本文运用有限元软件对曲线梁桥进行了梁体偏位分析,探讨了曲线梁桥荷载横向分布系数的计算方法,采用有限元计算方法。
简介:目的:观察新一代甘草酸制剂甘草酸二铵脂质配位体(DGLL)对酒精性脂肪肝的治疗作用.方法:用连续灌服(IG)酒精的方法建立大鼠酒精性脂肪肝模型,造模成功后给予药物治疗,以多烯磷脂酰胆碱(PPC)为对照,观察一般情况及测定血清肝功能指标和血脂参数,并对大鼠肝脏行病理学检查.结果:连续灌服(IG)酒精5周后大鼠形成酒精性脂肪肝,给药2周后,PPC与DGLL中剂量(500mg/kg)组能显著降低血中门冬氨酸氨基转移酶(AST)活性与肝中甘油三酯(TG)、总胆固醇(TC)含量,改善肝脏炎症活动度与脂肪性变,DGLL中剂量组还能显著降低血中TC、丙二醛(MDA)含量.结论:甘草酸二铵脂质配位体能改善酒精性脂肪肝大鼠体内脂质代谢,对酒精性脂肪肝具有一定的治疗作用.
简介:ApoptosisproducedinBcellsthroughFas(APO-1,CD95)triggeringisregulatedbysignalsderivedfromothersurfacereceptors:CD40engagementproducesupregulationofFasexpressionandmarkedsusceptibilitytoFas-inducedcelldeath,whereasantigenreceptorengagement,orIL-4Rengagement,inhibitsFaskillingandinsodoinginducesastateofFas-resistance,eveninotherwisesensitive,CD40-stimulatedtargets.SurfaceimmunoglobulinandIL-4RutilizeatleastpartiallydistinctpathwaystoproduceFas-resistancethatdifferentiallydependonPKCandSTAT6,respectively.Further,surfaceimmunoglobulinsignalingforinducibleFas-resistancebypassesBtk,requiresNF-κB,andentailsnewmacromolecularsynthesis.TerminaleffectorsofBcellFas-resistanceincludetheknownanti-apoptoticgeneproducts,Bcl-XLandFLIP,andanovelanti-apoptoticgenethatencodesFAIM(FasApoptosisInhibitoryMolecule).faimwasidentifiedbydifferentialdisplayandexistsintwoalternativelysplicedforms;faim-Sisbroadlyexpressed,butfaim-Lexpressionistissue-specific.TheFAIMsequenceishighlyevolutionarilyconserved,suggestinganimportantroleforthismoleculethroughoutphylogeny.InducibleresistancetoFaskillingishypothesizedtoprotectforeignantigen-specificBcellsduringpotentiallyhazardousinteractionswithFasL-bearingTcells,whereasautoreactiveBcellsfailtobecomeFas-resistantandaredeletedviaFas-dependentcytotoxicity.InadvertentoraberrantacquisitionofFas-resistancemaypermitautoreactiveBcellstoescapeFasdeletion,andmalignantlymphocytestoimpedeanti-tumorimmunity.
简介:<正>ThesusceptibilityofprimaryBcellstoFas(APO-1,CD95)-mediatedapoptosisisregulatedbysignalsderivedfromadditionalsurfacereceptors.CD40engagementproducesupregulationofFasexpressionandinducesmarkedsensitivitytoFas-inducedcelldeath,whereasBcellantigenreceptor(BCR)engagementinhibitsFaskillingandtherebyproducesFas-resistance,eveninotherwisesusceptible,CD40-stimulatedtargets.BCRsignalingforinducibleFas-resistancedevelopsoveraperiodof12hoursanddependson
简介:摘要以数据为驱动,以价值为导向,围绕“现代能源服务”战略,通过创新实践,依托传统文化体系构建“四位一体”数据文化培育体系。以精神层条件为“内核”,开展数据资源战略研究、专题讲座,全面升华数据意识;以制度层为“保障”,成立数据管理委员会,制定数据资产实施细则,实现文化的管理效力;以行为层为“桥梁”,积极组织培训筹办比赛,探索推动实际实践工作;以物质层为“基础”,推进“四库”建设,降低技术使用门槛,提供数据活动基本条件。最终形成相辅相成、迭代反馈、螺旋递进的数据文化培育体系。
简介:我在阅读了《晚晴》6~10期后,被《晚晴》"封面人物"、"封面写意"、"人物专访"三位一体的编辑风格深深吸引,这样的安排,层次鲜明、步步深入、环环紧扣。拿到《晚晴》,首先进入眼帘的就是封面人物,大幅照片给人强烈的视觉冲击,在封面要目上,开门见山提供了封面人物的姓名与事迹。翻到第三页,"封面