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简介：目的：观察推拿结合药物治疗婴幼儿轮状病毒感染性腹泻的临床疗效。方法：将确认的55例患儿按就诊先后随机分为2组。药物组30例，采用静脉滴注利巴韦林、口服思密达治疗；推拿加药物组25例，进行补脾经、清大肠、顺时针摩腹揉脐、推上七节骨、揉龟尾、捏脊等推拿手法治疗。并配合与药物组相同的药物治疗。结果：推拿加药物组总有效率96％，与药物组相比，P〈0．01。结论：推拿对治疗轮状病毒感染的婴幼儿腹泻具有良好的治疗效果，对于缩短病程、提高疗效、降低医疗费具有重要意义。

简介：INTRODUCTIONAmajorfunctionoftheintestinalepitheliumistocontroltheamountoffluidenteringintoandbeingabsorbedfromthelumen.Inhealthyconditions,netfluidmovementfollowsanabsorptivevector,althoughsignificantsecretionalsotakesplacetosubservedigestivefunction.Thus,the

简介：Tianshu(ST25),Zhongwan(CV12),Qihai(CV6),Zusanli(ST36)andetcwereselectedtotreatchronicdiarrhea.Thecurativeeffectbetweengingermoxibustionandacupuncturewascompared.Theeffectiverateoftwogroupswasrespectively93%and82%.

简介：AbstractThe aim of this study was to perform an epidemiological analysis of the viral strains isolated from outpatients with acute gastroenteritis in Dalian, Liaoning province, China to determine the epidemiology of Norovirus (NoV). Fecal samples were collected from 789 outpatients with acute gastroenteritis in the Xigang district of Dalian, Liaoning province, China from July 2015 to December 2016. Norovirus was detected by real-time reverse transcriptase-polymerase chain reaction (RT-PCR). A selection of the positive samples identified was subsequently sequenced, and these data were analyzed by using the Norovirus Typing tool. Results showed that 38.02% (300/789) of the fecal samples were positive for NoV, of which 95.67% (287/300) were identified as genotype GII with 1.33% (4/300) identified as GI. A further 3.00% (9/300) were combined infections with both GI and GII Norovirus. When analyzing the age distribution, the infections primarily occurred in adults especially the elderly whose NoV positive rate was much higher than the average. Winter was the season when most cases were recorded during 2015 and 2016; however, another infection peak was observed in July 2016. Thirty Norovirus positive samples were successfully sequenced, and results showed that GII.4 was the most commonly identified genotype, along with GII.3 and GII.17. Norovirus is the most common pathogen for acute gastroenteritis in Dalian, Liaoning province of China. The current NoV genotype prevalence in Dalian was found to be similar to that in other regions of China. Genotype GII.4 was the most common genotype in our study, GII.3 and GII.17 were also identified.

简介：AbstractSwine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently discovered coronavirus that causes severe and acute diarrhea and rapid weight loss in piglets. SADS-CoV was reported to be capable of infecting cell lines derived from diverse species, including bats, mice, hamsters, rats, chickens, pigs, nonhuman primates, and humans, implying its high risk of cross-species infection. However, its receptor is still unknown. In this study, the receptor-binding domain of the SADS-CoV spike (S) protein was purified and then subjected to affinity purification (AP)-coupled mass spectrometry (MS)-based proteomic analysis to identify the interactors of the SADS-CoV S protein. Forty-three host proteins were identified, and a Gene Ontology analysis indicated that these interactors can be grouped into categories such as "cell-cell adhesion" , "translation" "viral transcription" , suggesting that these processes may participate in the SADS-CoV life cycles. RNA interference-based screening of these interactors indicated that PPIB and vimentin can affect SADS-CoV replication. Our study provides an overarching view into the host interactome of the SADS-CoV S protein and highlights potential targets for the development of therapeutics against SADS-CoV.

简介：Objective:Toreviewyear1957-2005literatureonacupunctureandmoxibustionandexplorepointselectionandmethodsforacupuncture-moxibustiontreatmentofdiarrheainordertoprovideobjectiveandreliabledataforresearchonacupunctureandmoxibustionstandardization.

简介：Thispaperreportedthat2785in-patientswithinfantilediarrheaweretreatedwithmoxaconemainlyonpointsHegu(LI4),Zhongwan(CV12),Shenque(CV8),Zusanli(ST36)andPishu(EL20).Asaresult,2520cases(90.5%)weretreatedwithexcellenttherapeuticef-fectiveness;233(8.4%),good,and32(1.1%),poor.Thetotaleffectiveratereached98.9%.

简介：Totreat50casesofchronicdiarrheabylaserpoint-radiationonShenque(CV8),Tianshu(ST25),Zusanli(ST36)andPointAnti-diarrheawithlowpowerHe-Nelaser.Thetotaleffectiveratewas96%.

简介：在腹泻占优势的急躁的肠症候群(IBS-D)上观察针灸和艾灸的临床的效果。

简介：AIM:Todeterminethebowelsymptomsassociatedwithdiabetesanddiabetes-relatedfactorsafterexcludinggastrointestinal(GI)organicdiseases.METHODS:Participantswere4738(603diabeticand4135non-diabetic)patientswhounderwentcolonoscopyandcompletedaquestionnaire.Onthedayofpre-colonoscopy,9symptoms(borborygmus,abdominaldistension,increasedflatus,constipation,diarrhea,loosestools,hardstools,fecalurgency,andincompleteevacuation)wereprospectivelyevaluatedona7-pointLikertscale.Thetest-retestreliabilityofthebowelsymptomscoresfromthebaselineandsecondquestionnaireswasanalyzedusingkappastatistics.Associationsbetweenbowelsymptomscoresanddiabetesordiabetes-relatedfactorswereanalyzedbyarank-orderedlogisticmodeladjustedforrelatedconfounders,andoddsratios(ORs)wereestimated.RESULTS:Inmultivariateanalysis,constipation[adjustedoddsratio(AOR)=1.57,CI:1.33-1.85,P<0.01]andhardstools(AOR=1.56,CI:1.33-1.84,P<0.01)wereassociatedwithdiabetes,andfecalurgency(AOR=1.16,CI:0.99-1.37,P=0.07)andincompleteevacuation(AOR=1.16,CI:1.00-1.36,P=0.06)weremarginallyassociatedwithdiabetes.ThesesymptomsremainedassociatedevenafterexcludingorganicGIdiseasesoncolonoscopy.Test-retestreliabilityofsymptomscorewithameandurationof3.2mowasgood(meankappa,0.69).Associationsofsymptomswithdiabetes-relatedfactorswerefound;constipationwithHbA1c≥8.0%(AOR=2.11,CI:1.19-3.73),bodymassindex(BMI)<25(AOR=2.11,CI:1.22-3.66),andinsulinuse(AOR=1.90,CI:1.08-3.36);hardstoolswithdiabetesduration(AOR=1.03,CI:1.00-1.07);fecalurgencywithBMI<25(AOR=1.73,CI:1.00-2.98);andincompleteevacuationwithBMI<25(AOR=2.60,CI:1.52-4.43),serumcreatininelevel(AOR=1.27,CI:1.10-1.47),andinsulinuse(AOR=1.92,CI:1.09-3.38).CONCLUSION:Diabetesisassociatedwithconstipation,hardstools,fecalurgency,andincompleteevacuation,andpoorglycemiccontrol,duration,leanness,andnephropathyaffecttheriskofthesesymptoms.

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简介：AbstractImportance:Clostridium difficile-associated diarrhea (CDAD) is a severe type of antibiotic-associated diarrhea (AAD). However, the risk factors for CDAD in children with AAD have not yet been clarified.Objective:To investigate the distribution and risk factors for CDAD among hospitalized children in Beijing Children’s Hospital.Methods:Stool samples from 197 children with AAD were tested for the C. difficile pathogenic genes (tcdA, tcdB, tcdC, tcdD, tcdE, cdtA, and cdtB) using polymerase chain reaction between January 2011 and January 2014. Children who tested positive for tcdA or tcdB were included in the CDAD group, and those remaining comprised the non-CDAD group.Results:The rate of CDAD among the 197 children with AAD was 42.6% (84/197). The age distribution was 1-15.6 years, among which the majority of children (54.8%, 46/84) were aged 1-4 years. Differences in the CDAD-positive rates among AAD children belonging to different age groups were not statistically significant. Univariate analysis revealed that the duration of antibiotic therapy, the length of hospitalization prior to diarrhea, and gastrointestinal tract operations were significant risk factors (P < 0.05). Children with CDAD underwent more antibiotic therapy and had longer periods of hospitalization prior to diarrhea onset than children in the non-CDAD group. Using multivariate regression analysis, hospitalization for ≥ 10 days prior to diarrhea was found to be an independent risk factor for CDAD.Interpretation:This study revealed that the length of hospitalization (≥ 10 days) prior to diarrhea was an independent risk factor for CDAD in children with AAD.

简介：Totreat30casesofdiarrheaofinsufficiencyofthespleen-yangtypebymoxibustionwithsaltatShenque(CV8).Thetotaleffectiveratewas93.3%.